Turkish Journal of Zoology
Abstract
Montelukast sodium (MS) is a leukotriene receptor antagonist and used clinically as an antiasthma agent. MS has been hypothesized to have adverse effects in insects. To test this hypothesis, MS was added to the artificial diet of the fruit fly Drosophila melanogaster Meigen (Diptera: Drosophilidae) at different concentrations (1200, 1600, 2000, and 2400 mg/L) under laboratory conditions. The effects of MS on the survival rate and development time of D. melanogaster, as well as its effects on malondialdehyde (MDA) levels and cytochrome P450 monooxygenase (CYP450) enzyme activity in adults were investigated. The genotoxic effect of MS in whole adults was examined using a single-cell gel comet assay. Compared with the control, dietary MS concentrations led to decreased survivorship in each developmental stage of the insects. MDA content was significantly higher in adults reared on MS diets at 2400 mg/L. In addition, low MS concentrations significantly decreased CYP450 enzyme activity in the adults. MS resulted in significantly more DNA damage. This study confirms that oxidative stress and DNA damage are induced by dietary exposure to MS in D. melanogaster adults, adversely affecting survivorship. These findings have important implications in the control of agricultural pest insects.
Author ORCID Identifier
CİHAT ÇELİK: 0000-0002-2400-3412
DOI
10.55730/1300-0179.3238
Keywords
Drosophila melanogaster, montelukast sodium, oxidative stress, genotoxicity, detoxification enzyme
First Page
324
Last Page
334
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
ÇELİK, C (2025). The effects of montelukast sodium on some biological and biochemical aspects, DNA damage in Drosophila melanogaster adults. Turkish Journal of Zoology 49 (6): 324-334. https://doi.org/10.55730/1300-0179.3238
