Review on antimicrobial peptides from Malaysian amphibian resources: status, researchapproaches and ways forward

Authors

DASI ONG
SHAHRIZA SHAHRUDIN
MOHD NAZRI ISMAIL

DOI

10.3906/zoo-2011-8

Abstract

Antimicrobial resistance (AMR) is a significant threat to human health globally. Diseases caused by AMR are getting more challenging to cure due to the increasing rate of resistance of microbial pathogens. Drugs formulated with antimicrobial peptide (AMP) can be applied to treat these diseases. AMPs are found naturally within organisms, especially amphibians, and is related to the high adaptability of defence mechanisms against various pathogens and predators in the environment. This review focuses on the current status of research works and the different approaches applied to stimulate and collect amphibian secretions, extract and identify peptides, and conduct antimicrobial assays. The concerns of AMR include human health, animal health, economy, and agriculture. This section provides an overview of the potential uses of AMPs from Malaysian amphibians, other than their antibacterial and antifungal properties. The exploration of AMP on other amphibian species and the recommended steps for protein/AMP profiling via mass spectrometry are also included.

Keywords

Anura, antimicrobial resistance, antiviral, secretion, foam nest, mass spectrometry, protein profiling

First Page

79

Last Page

90

Recommended Citation

ONG, DASI; SHAHRUDIN, SHAHRIZA; and ISMAIL, MOHD NAZRI (2021) "Review on antimicrobial peptides from Malaysian amphibian resources: status, researchapproaches and ways forward," Turkish Journal of Zoology: Vol. 45: No. 2, Article 1. https://doi.org/10.3906/zoo-2011-8
Available at: https://journals.tubitak.gov.tr/zoology/vol45/iss2/1