Turkish Journal of Zoology




In this study, 4.3 µg/g cimetidine and 17 µg/g ranitidine were orally given to mice for two months. The effects of cimetidine and ranitidine on kidney cortical tissue were examined at light microscopical level. In both groups, it was detected that the tubules were separated by their lumen containing darkly stained remnant material. Vacuolization, destruction of apical membrane and decreased PAS positive reaction were observed in the apical membrane of proximal tubule epithelial cells. The nuclei of proximal and distal tubule cells were cylindrical. More excessively in the ranitidine treated group, widening of the tubule lumens and limited proximal tubule lobulation were observed. On the other hand, invagination of some distal tubules towards the lumen was detected. In conclusion, both drugs were found to be effective on kidney cortical tissue.


Cimetidine, ranitidine, kidney, mouse.

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