Turkish Journal of Veterinary & Animal Sciences




There are several known hereditary diseases in Arabian horses. Many studies have been conducted on molecular diagnostic methods of the mutations that cause these hereditary defects in horses. A five-base deletion in the short arm (ECA9p12) of the equine chromosome 9, starting with codon 9480, which occurs in the catalytic subunit gene of the DNA-dependent protein kinase (DNAPKcs) results in severe combined immunodeficiency (SCID) hereditary disorder. SCID is an autosomal recessive disorder wherein the immune system of the affected foal is very weak. Purebred Turkish Arabian horses reared in the Eskişehir region have contributed greatly to Turkish Arabian horse breeding and racing. The aim of this study was to detect the SCID mutant allele by using DNA sequencing analysis in Turkish Arabian horses, raised in nine different private farms in Eskişehir. It was determined that none of the horses evaluated in this study carried the SCID mutant allele.


DNA sequencing analysis, heritable disorders, SCID, Turkish Arabian horses

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