In this study, the effects of steroid substances such as corticosterone, progesterone, estrone, beta-sitosterol, and stigmasterol on some bacteria were investigated. In the research, standard strains of the gram-positive bacteria Bacillus subtilis (lab isolate) and Staphylococcus aureus (ATCC 6538) and the gram-negative bacteria Escherichia coli (ATCC 25922), Pasteurella multocida (ATCC 12945), and Pseudomonas aeruginosa (ATCC 9027) were used. A modified broth dilution method was applied for determining the minimal inhibitory concentration (MIC) of the steroids. Mueller Hinton broth (Becton Dickinson, 211443) was used to prepare dilutions and as a medium. At the end of the study, the MIC of corticosterone for P. multocida and the MIC of beta-sitosterol for S. aureus were both determined as 32 μg/mL. However, other steroids showed no effects on the bacteria. These steroids did not appear to have widespread antibacterial properties.
Corticosterone, progesterone, estrone, beta-sitosterol, stigmasterol, antibacterial
DOĞAN, ABDULLAH; OTLU, SALİH; ÇELEBİ, ÖZGÜR; AKSU, PINAR; SAĞLAM, ALİYE GÜLMEZ; DOĞAN, ALİ NAZMİ CAN; and MUTLU, NESLİHAN
"An investigation of antibacterial effects of steroids,"
Turkish Journal of Veterinary & Animal Sciences: Vol. 41:
2, Article 22.
Available at: https://journals.tubitak.gov.tr/veterinary/vol41/iss2/22