Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs

Authors

PINAR CAN
ÖMER BEŞALTI
EYLÜL AKPINAR
ZEYNEP AKTAŞ
AYŞE ESER ELÇİN
YAŞAR MURAT ELÇİN

DOI

10.3906/vet-1506-21

Abstract

The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in two dogs suspected to have fibrocartilaginous embolic myelopathy (FCEM). Both dogs were paraplegic without deep pain perception (DPP) and tentatively diagnosed by MRI. Autologous NIBM-MSCs (5 × 106) were transplanted into the lumbar subarachnoid space two times with a 21-day interval for each patient. Based on a 21-month follow-up of the treated animals, the transplantation of NIBM-MSCs seems to be promising in subjects with FCEM lacking DPP.

Keywords

Dog, subarachnoid transplantation, mesenchymal stem cells

First Page

120

Last Page

123

Recommended Citation

CAN, PINAR; BEŞALTI, ÖMER; AKPINAR, EYLÜL; AKTAŞ, ZEYNEP; ELÇİN, AYŞE ESER; and ELÇİN, YAŞAR MURAT (2016) "Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs," Turkish Journal of Veterinary & Animal Sciences: Vol. 40: No. 1, Article 19. https://doi.org/10.3906/vet-1506-21
Available at: https://journals.tubitak.gov.tr/veterinary/vol40/iss1/19