Screening for S32G mutation of BMP15 gene in 18 goat breeds

Authors

TAO FENG
MING-XING CHU
GUI-LING CAO
DONG-WEI HUANG
RAN DI
QIU-YUE LIU
ZHANG-YUAN PAN
MEI JIN
YING-JIE ZHANG

DOI

10.3906/vet-1401-97

Abstract

In our early work, one mutation (A898G, which caused Ser32Gly (S32G) change of mature peptide) was identified in the goat BMP15 gene and the allele G was associated with high litter size in Jining Grey goats (the goat breed with the highest fecundity in China). The aim of this research was to investigate the genetic structure of the prolific BMP15 gene in 18 goat breeds reared in China, including 12 native breeds, 3 introduced breeds, and 2 cultivated breeds. Genomic DNA of 1011 goats was screened for the S32G mutation. The results showed that this mutation existed in all 3 cultivated and 8 native goat breeds but in none of the 3 introduced goat breeds, which hinted that this mutation may originate from native goat breeds of China. Besides the Jining Grey goats, the BMP15 gene was also a potential prolificacy gene in Matou goats. Moreover, the structure prediction indicated that the S32G mutation might participate in the binding of BMP15 with receptors.

Keywords

Goat, prolificacy, bone morphogenetic protein 15 gene, functional analysis

First Page

463

Last Page

468

Recommended Citation

FENG, TAO; CHU, MING-XING; CAO, GUI-LING; HUANG, DONG-WEI; DI, RAN; LIU, QIU-YUE; PAN, ZHANG-YUAN; JIN, MEI; and ZHANG, YING-JIE (2014) "Screening for S32G mutation of BMP15 gene in 18 goat breeds," Turkish Journal of Veterinary & Animal Sciences: Vol. 38: No. 5, Article 1. https://doi.org/10.3906/vet-1401-97
Available at: https://journals.tubitak.gov.tr/veterinary/vol38/iss5/1