Impact of the Haberlea rhodopensis extract on the innate immune system and response in rabbits following KLH-hemocyanin immunization and cyclophosphamide treatment

Authors

SVETLANA GEORGIEVA
LILIAN SOTIROV
BORISLAV POPOV
TSVETOSLAV KOYNARSKI

DOI

10.3906/vet-1301-51

Abstract

The aim of the present investigation was to study the impact of Haberlea rhodopensis extract on the innate immune response in rabbits. The complement and lysozyme activity, percent phagocytosis, and phagocytic index were studied. The analysis of the results showed that the treatment with Haberlea rhodopensis extract, cyclophosphamide, and KLH renders a remittent effect upon the classical pathway of activation of the complement system and the lysozyme concentration in the rabbit blood serum. These same factors have no direct effect on the phagocytic activity in the investigated animals. The obtained data show limited effect of Haberlea rhodopensis extract on rabbits’ natural immunity.

Keywords

Haberlea rhodopensis, cyclophosphamide, complement, lysozyme, phagocytic activity

First Page

659

Last Page

663

Recommended Citation

GEORGIEVA, SVETLANA; SOTIROV, LILIAN; POPOV, BORISLAV; and KOYNARSKI, TSVETOSLAV (2013) "Impact of the Haberlea rhodopensis extract on the innate immune system and response in rabbits following KLH-hemocyanin immunization and cyclophosphamide treatment," Turkish Journal of Veterinary & Animal Sciences: Vol. 37: No. 6, Article 8. https://doi.org/10.3906/vet-1301-51
Available at: https://journals.tubitak.gov.tr/veterinary/vol37/iss6/8