Turkish Journal of Veterinary & Animal Sciences
Abstract
Changes in the level of malondialdehyde (MDA, a degradative product of lipid peroxidation) and in the antioxidant defense system in rats with carbon tetrachloride-induced liver cirrhosis were studied, in order to determine whether there is any relation between these parameters and the disease. Liver cirrhosis was induced in Wistar-Albino rats by carbon tetrachloride (0.15 gr/100 gr body weight) which was injected subcutanously three times a week for six weeks. In the liver, the level of tissue malondialdehyde was analysed according to Yagi's method; and glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase activities according to Beutler's method. The level of liver malondialdehyde in the group with cirrhosis was significantly higher than in the control group (p
DOI
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Keywords
Cirrhosis, lipid peroxidation, glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase.
First Page
25
Last Page
28
Recommended Citation
YILMAZ, S, & BAHÇECİOĞLU, İ. H (2000). Lipid Peroxidation, Antioxidant Enzymes and Pyruvate Kinase Activity in Rats With CarbonTetrachloride-Induced Cirrhosis. Turkish Journal of Veterinary & Animal Sciences 24 (1): 25-28. https://doi.org/-