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Turkish Journal of Veterinary & Animal Sciences

DOI

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Abstract

Some pharmacokinetic parameters and concentrations of four antimicrobial agents in plasma and lymph fluids were compared for determination of penetration into peripheral tissues. Eighteen healthy, adult sheep (Turk Merino x Hampshire cross, 18-24 month, weighing 32-37 kg) were used. For collection of lymph samples, the efferent vessel of NI. cervicalis superficialis sinister was cannulated with a polyethylene catheter. All antimicrobial agents were administered intramuscularly at single recommended doses (Chloramphenicol 30 mg/kg b.wt., Enrofloxacin 2.5 mg/kg b. wt., Sulphadoxine-trimethoprim 16 mg/kg b.wt.). Subsequently, blood and lymph samples were concurrently obtained at 2, 4, 8, 12, 16 and 24 hr postinjection. Concentrations of these agents in all samples were analysed by HPLC. Concentrations of enrofloxacin in lymph fluids at all sampling times were found to be higher than plasma (p0.05). The level of chloramphenicol in plasma was found to be higher than lymph fluid only at 2 hr (p

First Page

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