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Turkish Journal of Veterinary & Animal Sciences

Article Title

Ultrasonographic Evaluation of Kidney Damage in Dog with Gentamicin Nephrotoxicity

DOI

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Abstract

Acute tubular necrosis was induced by experimental gentamicin nephrotoxicity to follow and describe the changes in ultrasonographic appearance of the kidney. Sonograms were evaluated for information on size, shape and renal structure, specifically including focal, multifocal, or diffuse alterations in renal cortical, medullar, sinusal and perinephric echogenity and intensity (compared to that of the splenic and hepatic paranchmys). Following 12 hours of no feeding, clinical, biochemical and ultrasonographic examinations were conducted and then gentamicin sulphate (10 mg/kg body weight, t.i.d.) was injected for 10 consecutive days. The clinical states of the dogs were observed, and urine dip stick examinations, microscopic examination of urine sediment, biochemical [blood: BUN, serum creatinine (CR), albumin PO4-,Na+,K+ concentrations; urine: total protein (TP) and creatinine concentrations, N-acetyl-b-D-glucosaminidase (NAG), g-glutamly transferase (GGT), alkaline phosphates (ALP) activities and their creatinine rations, fractional clearences of Ca2+, PO4-, Na+,K+] analysis and ultrasonographic examinations of the kidneys were performed every other day for 15 days. Heamaturia, proteinuria, glucosuria and granular casts in the microscopic examination of urine sediment were first determined on the 8th day of the experiment. BUN, serum CR and PO4- and K+ concentrations were significantly increased on the 3rd, 9th, and 13th days of the experiment, respectively (p

First Page

367

Last Page

373

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