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Turkish Journal of Medical Sciences

Abstract

The original article can be accessed at https://doi.org/10.55730/1300-0144.6192.

Background/aim: Subarachnoid haemorrhage (SAH) is a severe cerebrovascular condition with high morbidity and mortality. Inflammation and oxidative stress are key factors in its pathophysiology, particularly in secondary vascular injury. This study aimed to evaluate the effects of colchicine on vascular integrity and biochemical markers following SAH in an experimental rat model.

Materials and methods: Eighteen female Sprague-Dawley rats were divided into three groups: Control (no SAH), SAH (induced without treatment), and SAH + Colchicine (1 mg/kg intraperitoneally at 1 h and 24 h). SAH was induced by autologous blood injection into the cisterna magna. Rats were sacrificed 48 h post-induction. Serum and tissue samples were analyzed for oxidative stress indices and inflammatory cytokines, and histopathological evaluations were performed to assess vascular injury.

Results: SAH caused significant increases in oxidative stress and pro-inflammatory cytokines compared to the Control group. Tissue TOS and OSI levels were higher, while TAS was lower in both SAH and colchicine groups (p < 0.05). Serum cytokines (IL-1β, IL-6, TNF-α) and OSI were highest in the colchicine group, intermediate in SAH, and lowest in Control, whereas TAS showed the opposite pattern (p < 0.05). Thiol-disulfide homeostasis shifted toward oxidation, with reduced total/native thiols and elevated disulfide ratios. Histologically, colchicine partially reduced endothelial damage and inflammation, but basilar artery diameter and wall thickness remained unchanged.

Conclusion: At the administered dose and 48-hour time point, colchicine produced partial histological improvement without reducing systemic oxidative or inflammatory markers. Some serum indices were higher than in untreated SAH, suggesting a limited short-term protective effect. Further studies are required to explore optimal dosing and timing for colchicine as a potential neuroprotective agent

Author ORCID Identifier

EMİNE DEMİR: 0000-0003-4352-4720

CUMAALİ DEMİRTAŞ: 0000-0001-5226-6730

CANSU SÖNMEZ: 0000-0003-3595-5088

ERAY GÜLER: 0000-0003-4351-1719

SARPER KOCAOĞLU: 0000-0001-6092-3614

HAKAN BEYAZTAŞ: 0000-0003-3706-5193

EYÜP ÇETİN: 0000-0002-2045-6721

DOI

10.55730/1300-0144.6379

Keywords

Subarachnoid haemorrhage, colchicine, oxidative stress, inflammation, cerebrovascular circulatio

First Page

1352

Last Page

1363

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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