Turkish Journal of Medical Sciences
Abstract
Background/aim: Parenteral feeding is used in critically ill patients when enteral nutrition is inadequate or intolerable, and the gastrointestinal tract is not functioning properly. Lipid emulsions play a major role in parenteral nutrition because they supply necessary fatty acids and a high-calorie density. We investigated the effects of parenteral lipid emulsions on mesenteric perfusion, inflammation-induced oxidation, and organ damage in lipopolysaccharide-induced mice endotoxemia model.
Materials and methods: In septic mice, organ damage induced by lipopolysaccharide was assessed by histopathology and biochemical examination. Additionally, an ultrasonic blood flowmeter was used to measure the impact of lipid emulsions on mesenteric blood flow.
Results: When compared to control animals, mesenteric blood flow was reduced by parenteral lipid emulsions containing fish oil, soybean oil, and olive oil; however, when compared to the lipopolysaccharide group, the decrease in mesenteric blood flow was avoided by fish oil therapy. Lipid emulsions could not hinder the increase in liver and spleen weight caused by lipopolysaccharide injection. In septic mice, fish oil reduced liver damage, whereas in control animals, specific dosages of olive and soybean oils resulted in histopathologically significant liver and spleen damage. Parenteral lipid emulsions have shown an organ-specific impact on compromised oxidative equilibrium.
Conclusion: Fish oil emulsions containing high omega-3 fatty acids abrogate the decrease in mesenteric blood flow and prevent liver damage in this experimental endotoxemia model.
Author ORCID Identifier
GÖKŞEN ÖZ: 0000-0003-2004-5241
ESİN ÖZÇELEBİ: 0000-0001-9431-9546
AYŞE GÖÇMEN: 0000-0002-8511-639X
CENK SÜKMENSÜER: 0000-0001-7637-8745
SELMA YILDIRIM: 0000-0002-5925-561X
ARZU TOPELİ: 0000-0002-5874-9087
ALPER İSKİT: 0000-0002-7258-8902
DOI
10.55730/1300-0144.6224
Keywords
fish oil, Intensive care, lipid emulsions, omega-3 fatty acids, parenteral nutrition, sepsis
First Page
897
Last Page
906
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
ÖZ, G, ÖZÇELEBİ, E, GÖÇMEN, A. Y, SÜKMENSÜER, C, YILDIRIM, S, TOPELİ, A, & İSKİT, A. B (2026). Omega-3–rich fish oil lipid emulsions significantly prevent sepsis-driven mesenteric hypoperfusion and multi-organ injury in murine models. Turkish Journal of Medical Sciences 56 (3): 897-906. https://doi.org/10.55730/1300-0144.6224
