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Turkish Journal of Medical Sciences

Abstract

Background/aim: Colchicine poisoning has been associated with systemic toxicity, multiple organ dysfunction syndrome (MODS), and mortality. In the present study, the demographic, clinical, and laboratory characteristics of pediatric colchicine poisoning cases and the incidence of organ failure are investigated to identify potential risk factors associated with MODS.

Materials and methods: Included in this retrospective multicenter cohort study were pediatric patients admitted to 28 tertiary-care pediatric intensive care units with a diagnosis of colchicine poisoning. Demographic data, clinical and laboratory findings, and clinical outcomes were extracted from medical records. MODS was defined as dysfunction involving at least two organ systems. Multivariable logistic regression analysis was performed to identify the variables independently associated with MODS.

Results: Of the 150 patients included in the study, 40% were younger than 5 years and 52% were older than 13 years. Gastrointestinal symptoms were most prominent, with nausea and vomiting observed in 64.7%, abdominal pain in 36.7%, and diarrhea in 24%. Overall, 66% developed no organ failure, while single-organ failure occurred in 7.3% and 26.7% developed MODS. The coagulation system was most frequently affected (26%), followed by the hematological (19.3%) and immunological (18%) systems. Multivariable logistic regression analysis identified the baseline PRISM III score, ingested colchicine dose per kilogram of body weight, and initial sodium, creatinine, and aspartate aminotransferase (AST) levels as independent predictors of MODS.

Conclusion: MODS can develop at ingestion doses lower than 0.5 mg/kg, which have historically been considered safe. Higher ingested doses and elevated PRISM III scores were associated with MODS, although these findings are derived from retrospective observational data and should not be interpreted as causal or as direct clinical recommendations. Further prospective studies are needed to clarify relevant doses, interventions, and prognostic factors in pediatric colchicine poisoning associated with MODS.

Author ORCID Identifier

FARUK EKİNCİ: 0000-0001-6675-3150

DİNÇER YILDIZDAŞ: 0000-0003-0739-5108

OZDEN ÖZGÜR HOROZ: 0000-0001-7590-650X

HAYRİ LEVENT YILMAZ: 0000-0003-0873-9814

SEVCAN BİLEN: 0000-0001-5065-8263

İLKER ÜNAL: 0000-0002-9485-3295

İKBAL TÜRKER: 0000-0002-6370-676X

ESRA ŞEVKETOĞLU: 0000-0002-8330-2877

NİHAL AKÇAY: 0000-0002-8273-2226

AGOP ÇITAK: 0000-0002-5108-3913

GÜNTÜLÜ ŞIK: 0000-0002-4526-0485

TANIL KENDİRLİ: 0000-0001-9458-2803

MERVE HAVAN: 0000-0003-3431-7906

MURAT KANGIN: 0000-0003-0042-0569

MEHMET NUR TALAY: 0000-0002-7361-3823

NAZİK YENER: 0000-0003-2469-0598

HATİCE ALBAYRAK: 0009-0006-0208-8298

EDİN BOTAN: 0000-0003-4586-1595

UTKU ÖZER: 0000-0003-3669-8853

ARZU OTO: 0000-0003-0229-2759

GÜRKAN BOZAN: 0000-0001-5041-8892

MUHTEREM DUYU: 0000-0001-7892-2927

BAŞAK NUR AKYILDIZ: 0000-0001-8540-0625

NAİME GÖKAY: 0000-0002-6890-7771

ELİF ÇELİK: 0000-0002-0298-4088

ÇAPAN KONCA: 0000-0001-8625-9045

MUTLU UYSAL YAZICI: 0000-0001-7377-4718

OĞUZ DURSUN: 0000-0001-5482-3780

FEYZA İNCEKÖY GİRGİN: 0000-0003-4324-0488

HATİCE FERAY ARI: 0000-0002-2208-2524

İLKNUR ARSLAN: 0000-0002-3454-8483

MURAT ÖZKALE: 0000-0003-0625-1057

ÖZLEM SANDAL: 0000-0002-5414-4670

MERVE MISIRLIOĞLU: 0000-0002-9554-841X

HALİL KESKİN: 0000-0003-4491-1327

SADIK KAYA: 0000-0002-6237-5831

ARDA KILINÇ: 0000-0001-9121-2188

FERHAT SARI: 0000-0002-9134-767X

FATİH AKIN: 0000-0001-5725-3867

AYŞE AŞIK: 0000-0003-0973-8098

IBRAHİM BİNGÖL: 0000-0002-6340-5000

EDA TURANLI: 0000-0001-5876-0510

MERVE BOYRAZ: 0000-0002-4158-0270

ENERENER ÇAĞRI DİNLEYİCİ: 0000-0002-0339-0134

MEHMET AKİF DÜNDAR: 0000-0003-3042-7999

SELVER CEREN ÖZCAN: 0000-0002-6724-5243

AYGÜL KAYA AKILLI: 0009-0003-8000-0018

EMİNE AKKUZU: 0000-0001-8698-5928

NAZAN ÜLGEN TEKEREK: 0000-0002-4577-1488

NİLÜFER ÖZTÜRK: 0000-0003-4805-4676

EMRAH GÜN: 0000-0001-7337-0190

YASEMİN ÖZKALE: 0000-0003-3009-336X

NURETTİN ONUR KUTLU: 0000-0002-3306-6570

ZEYNELABİDİN ÖZTÜRK: 0000-0001-8548-4144

DOI

10.55730/1300-0144.6204

Keywords

Colchicine, intensive care unit, organ dysfunction, pediatric, poisoning

First Page

708

Last Page

717

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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