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Turkish Journal of Medical Sciences

Abstract

Background/aim: To determine whether there is a possible link between selected preoperative systemic inflammatory markers and molecular pathological indices.Material and methods: For this retrospective study, 125 patients served as subjects. Preoperative systemic inflammatory markers, namely neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and postoperative pathological indices, namely mitosis, Ki-67 labeling index (LI), isocitrate dehydrogenase-1 (IDH1) mutation, and 1p/19q codeletion, were obtained from the electronic database.

Results: Results showed that NLR positively correlated with PLR (p = 0.00001), mitotic activity (p = 0.001), and Ki-67 LI (p = 0.00001). On the other hand, LMR negatively correlated with PLR (p = 0.00001), mitotic activity (p = 0.00001), Ki-67 LI (p = 0.001), and IDH1 mutation (p = 0.04).

Conclusion: Our results suggest a link between systemic inflammation and histopathology, and higher NLR and/or lower LMR may be a novel prognostic marker in gliomas. A prospective multicenter study with a larger patient population would be more convincing. Until such a study is published, the results of retrospective studies, including ours, should be evaluated with caution.

Author ORCID Identifier

SEMİH CAN ÇETİNTAŞ: 0000-0001-6036-164X

BURAK TAHMAZOĞLU: 0000-0002-9248-9960

TUFAN AGAH KARTUM: 0000-0003-1529-6476

RAHŞAN KEMERDERE: 0000-0002-9947-3486

TANER TANRIVERDİ: 0000-0002-1878-0696

DOI

10.55730/1300-0144.6143

Keywords

Gliomas, 1p/19q co-deletion, IDH1 mutation, Ki-67 labeling index, preoperative systemic inflammatory marker

First Page

107

Last Page

117

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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