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Turkish Journal of Medical Sciences

Abstract

Endocrine-disrupting chemicals (EDCs) are compounds that interfere with hormone synthesis, secretion, metabolism, or excretion. Evidence indicates that increased exposure to EDCs is associated with insulin resistance and, most notably, type 2 diabetes worldwide. This suggests a diabetogenic effect that is independent of obesity, underscoring the complex mechanisms and broad impact of EDCs on metabolic health. Key pathways include hormone mimicry and antagonism, altered hormone metabolism, inflammatory responses, and mitochondrial dysfunction. This review summarises the mechanisms through which EDCs contribute to these conditions and evaluates the epidemiological and experimental evidence supporting these associations.

Author ORCID Identifier

MERİÇMERIÇ COŞKUN: 0000-0003-4855-6078

ETHEM CERİT: 0000-0002-7518-388X

TUĞBA BARLAS: 0000-0003-0042-6928

ALEV EROĞLU ALTINOVAALTINOVA: 0000-0002-6707-7761

DOI

10.55730/1300-0144.6119

Keywords

diabetes, Endocrine disruptors, insulin resistance, T2D

First Page

1595

Last Page

1601

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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