Turkish Journal of Medical Sciences
Abstract
Endocrine disruptors are chemical substances widely utilized across various industrial sectors. Due to their structural similarity to natural ligands, they bind to receptors and influence the endocrine system via agonist–antagonist mechanisms. Exposure occurs through the consumption of contaminated food and water, inhalation of polluted air and dust, and dermal contact. Owing to their dynamic remodeling capacity, bones represent potential targets for endocrine-disrupting chemicals. These chemicals can disrupt bone formation, skeletal development, hormonal regulation, and calcium metabolism. Sensitivity to endocrine-disrupting chemicals is greatest during the prenatal and early postnatal periods. This review summarizes the effects of endocrine-disrupting chemicals on bone tissue.
Author ORCID Identifier
BETÜL GÜNDÜZ: 0000-0002-3945-2501
ELİF KILIÇ KAN: 0000-0002-9047-3121
AYŞEGÜL ATMACA: 0000-0001-6326-6365
DOI
10.55730/1300-0144.6128
Keywords
bone, Endocrine disrupting chemicals, osteoporosis
First Page
1664
Last Page
1670
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
GÜNDÜZ, B, KILIÇ KAN, E, & ATMACA, A (2025). Endocrine-disrupting chemicals in metabolic bone diseases, including osteoporosis. Turkish Journal of Medical Sciences 55 (7): 1664-1670. https://doi.org/10.55730/1300-0144.6128
