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Turkish Journal of Medical Sciences

Abstract

Background/aim: Although low phosphorus (P) concentrations are a recognized feature of primary hyperparathyroidism (PHPT), they are not among the diagnostic or surgical criteria. The present study evaluates the association between serum phosphorus levels and clinical outcomes in PHPT patients.

Materials and methods: A search of the Turkish Ministry of Health’s National Electronic Database was conducted using ICD-10 diagnostic codes and laboratory data to identify PHPT cases within the Turkish population from 2017 to 2022.

Results: The records of a total of 113,330 PHPT patients (77.5% female; mean age 58.9 ± 15.6 years) were analyzed, revealing a mean serum phosphorus level of 3.24 ± 0.79 mg/dL. Patients with nephrolithiasis, vitamin D <20 μg/L, and calcium ≥11.4 mg/dL had significantly lower phosphorus levels (p<0.0001). Hypophosphatemia (HypoP) (P < 2.5 mg/dL) was present in 14.3% of patients and was associated with higher parathyroid hormone, calcium, and alkaline phosphatase levels, and lower vitamin D levels (all p < 0.0001). HypoP independently increased the risk of kidney stone formation (OR = 1.53; 95% CI 1.46–1.61).

Conclusion: HypoPis associated with more severe biochemical abnormalities and a greater prevalence of nephrolithiasis in PHPT. In regions where vitamin D deficiency is common, low phosphorus levels may indicate more severe diseases, and so routine phosphorus monitoring should be considered as part of PHPT management.

Author ORCID Identifier

NAİM ATA: 0000-0001-6947-2821

BEKİR UÇANUCAN: 0000-0002-0810-5224

HALİL DURANTAŞ: 0009-0005-6249-1532

OĞULCAN BOZ: 0000-0003-2858-4207

MUSTAFA ŞAHİN: 0000-0002-4718-0083

MUSTAFA MAHİR ÜLGÜ: 0000-0003-0825-1851

ŞUAYİP BİRİNCİ: 0000-0001-8104-6198

MUHAMMED KIZILGÜL: 0000-0002-8468-9196

DOI

10.55730/1300-0144.6095

Keywords

Hypophosphatemia, primary hyperparathyroidism, renal stone

First Page

1372

Last Page

1380

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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