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Turkish Journal of Medical Sciences

Abstract

Background/aim: Radiofrequency ablation of solitary parathyroid adenoma has been used to treat primary hyperparathyroidism (pHPT) in high-risk patients for parathyroidectomy. This study aimed to evaluate the clinical efficacy of radiofrequency ablation for treating pHPT in patients with parathyroid adenomas.

Materials and methods: The sample for this retrospective study comprised all consecutive patients with solitary parathyroid adenoma treated with radiofrequency ablation between 2013 and 2021. Patients’ baseline serum calcium and parathyroid hormone (PTH) values were obtained. The patients were followed up with serial biochemical measurements after the intervention, then at the first-week, first-month, third-month, sixth-month, and twelfth-month follow-ups. The study’s primary outcome was a biochemical cure, defined as the reestablishment of normal serum calcium and PTH levels, persisting for at least 6 months after the ablation.

Results: The changes in the serum calcium and PTH levels were significant (p < 0.05). The biochemical cure rate was 30.2% at 1 year. At the end of 1 year, the rate of patients with normal serum calcium levels was 86.6%, whereas the rate of patients with normal serum calcium and higher PTH levels was 55.8%.

Conclusion: Radiofrequency ablation of a solitary parathyroid adenoma may be considered an alternative treatment for pHPT, given that more than half of the cases investigated in this study had normocalcemic hyperparathyroidism at 1 year.

Author ORCID Identifier

BAHRİ EVREN: 0000-0001-7490-2937

ABDULKADİR BOZBAY: 0000-0003-0592-159X

İSMAİL OKAN YILDIRIM: 0000-0002-3641-0103

ÖMERCAN TOPALOĞLU: 0000-0003-3703-416X

İBRAHİM ŞAHİN: 0000-0002-6231-0034

DOI

10.55730/1300-0144.6108

Keywords

hypercalcemia, parathyroid adenoma, Primary hyperparathyroidism, radiofrequency ablation

First Page

1497

Last Page

1503

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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