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Turkish Journal of Medical Sciences

Abstract

Background/aim: In-stent restenosis (ISR) remains a significant clinical challenge in patients undergoing percutaneous coronary interventions. We investigated the association between Prognostic Nutritional Index (PNI) and ISR in patients with chronic coronary syndrome.

Materials and methods: A total of 1007 patients who underwent coronary angiography for a provisional diagnosis of chronic coronary syndrome between March 1, 2019, and July 1, 2022, were included in the study. They were divided into two groups: ISR (n = 395) and non-ISR (n = 612). PNI was calculated using patients’ laboratory values before coronary angiography with the following formula: PNI = (10 × albumin (g/dL)) + (0.005 × total lymphocyte count (per mm3)).

Results: The mean age of the patients was 62 ± 10 years, and 75% of the patients (n = 760) were male. The calculated PNI was 42.83 ± 3.53 in the non-ISR group and 44.43 ± 3.74 in the ISR group (p < 0.001). When the validity of the PNI for ISR was statistically examined, the AUC was calculated as 0.64 (0.61–0.68). The cutoff value for PNI was determined to be 44, which predicted stent ISR with a sensitivity of 61% and a specificity of 61%.

Conclusion: Contrary to the findings in the literature, our study revealed a higher Prognostic Nutritional Index (PNI) value in the stent ISR group than in the non-ISR group. The PNI reflects the current nutritional status, whereas stent ISR is an outcome of a chronic clinical condition.

Author ORCID Identifier

BURAK KARDEŞLER: 0000-0003-4576-5798

SERDAL BAŞTUĞ: 0000-0002-1400-4614

KAMURAN KALKAN: 0000-0001-6204-316X

MEHMET ERDOĞAN: 0000-0002-2747-3823

FURKAN KÜLEKCİ: 0000-0001-6304-1908

MUHAMMED YUNUS ÇALAPKULU: 0000-0002-3828-7479

NUR BETON: 0009-0002-0066-2840

ABDULLAH NABİ ASLAN: 0000-0001-9392-3311

HAFİZE CORUT GÜZEL: 0000-0003-4007-4621

TAHİR DURMAZ: 0000-0001-5414-8543

DOI

10.55730/1300-0144.6082

Keywords

chronic coronary syndrome, in-stent restenosis, Prognostic nutritional index

First Page

1283

Last Page

1291

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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