Turkish Journal of Medical Sciences
Abstract
Background/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model.
Materials and methods: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured.
Results: Group 4 showed significantly lower EF grades compared with Groups 1 and 2 (p < 0.001), and reduced arachnoid invasion compared with Group 1 (p < 0.05). Group 4 had the lowest hydroxyproline levels (1.19 ± 0.05 μg/mL), followed by Group 3 (1.48 ± 0.16 μg/mL), Group 2 (1.67 ± 0.24 μg/mL), and Group 1 (1.94 ± 0.30 μg/mL) (all p < 0.001).
Conclusion: Hesperidin significantly reduced EF and collagen deposition in a dose-dependent manner, demonstrating its potential as a preventive agent for FBSS.
DOI
10.55730/1300-0144.6080
Keywords
Epidural fibrosis, hesperidin, antifibrotic effect, in vivo
First Page
1265
Last Page
1274
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
KESKİN, E, & GEL, M. S (2025). Hesperidin efficacy of epidural fibrosis in a post laminectomy rat model: an experimental study. Turkish Journal of Medical Sciences 55 (5): 1265-1274. https://doi.org/10.55730/1300-0144.6080
