Sinapic acid alleviates renal ischemia-reperfusion injury by regulating oxidative stress, apoptosis, and inflammation

Authors

MUSTAFA CAN GÜLERFollow
FAZİLE NUR EKİNCİ AKDEMİRFollow
ERSEN ERASLANFollow
AYHAN TANYELİFollow
DERYA GÜZEL ERDOĞANFollow
BEHZAT TEBRİZİFollow

Abstract

Background/aim: Acute kidney injury (AKI) is a major clinical issue, frequently resulting from ischemia-reperfusion (I/R) injury. Sinapic acid (SA), a natural phenolic molecule included in numerous plant-based foods, exhibits antiapoptotic, antioxidant, and antiinflammatory properties. This study aimed to investigate the renoprotective effects of SA in an I/R-induced acute kidney injury (AKI) model.

Materials and methods: Sprague–Dawley male rats (n = 32) were randomly assigned to four groups: sham, I/R, SA 20 mg/kg, and SA 40 mg/kg. SA was administered intraperitoneally before reperfusion. Renal tissues were examined using biochemical, histopathological, and immunohistochemical methods, focusing on oxidative stress, cytokine expression, and apoptosis markers.

Results: I/R induced significant oxidative stress, elevated proinflammatory cytokines, and tubular damage. Treatment with SA, particularly at 40 mg/kg, significantly improved antioxidant defenses, reduced inflammatory cytokine levels, and attenuated tubular necrosis and apoptosis, as confirmed by decreased caspase-3 and HAVCR1 (also known as KIM-1) expression.

Conclusion: SA significantly ameliorated renal I/R injury by modulating apoptosis, inflammation, and oxidative stress. These findingssupport the therapeutic efficacy of SA in AKI and highlight the need for further translational research.

Author ORCID Identifier

MUSTAFA CAN GÜLER: 0000-0001-8588-1035

FAZİLE NUR EKİNCİ AKDEMİR: 0000-0001-9585-3169

ERSEN ERASLAN: 0000-0003-2424-2269

AYHAN TANYELİ: 0000-0002-0095-0917

DERYA GÜZEL ERDOĞAN: 0000-0002-7618-5043

BEHZAT TEBRİZİ: 0000-0002-9075-7239

DOI

10.55730/1300-0144.6052

Keywords

apoptosis, inflammation, oxidative stress, renal ischemia-reperfusion, Sinapic acid

First Page

992

Last Page

1002

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

GÜLER, M, EKİNCİ AKDEMİR, F, ERASLAN, E, TANYELİ, A, GÜZEL ERDOĞAN, D, & TEBRİZİ, B (2025). Sinapic acid alleviates renal ischemia-reperfusion injury by regulating oxidative stress, apoptosis, and inflammation. Turkish Journal of Medical Sciences 55 (4): 992-1002. https://doi.org/10.55730/1300-0144.6052