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Turkish Journal of Medical Sciences

Abstract

Background/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the Systemic Immune-Inflammation Index (SII) and the Pan-Immune-Inflammation Value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye [University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (January 1, 2015–October 1, 2022) and Etlik City Hospital (October 1, 2022–March 11, 2025)]. Demographic, clinical, and laboratory data, along with treatment details and outcomes (discharge or in-hospital death), were systematically recorded.

Results: A total of 76 patients were included, of whom 92.1% were male, with a mean age of 49.0 ± 12.4 years. During hospitalization, 48.6% (n = 37) died. Both SII and PIV values at admission were significantly higher in non-survivors (p < 0.001 for SII; p = 0.031 for PIV). In multivariate Cox regression analysis, higher SII (HR: 2.44; 95% CI: 1.05–5.67; p = 0.034) and PIV (HR: 2.08; 95% CI: 1.05–4.13; p = 0.030) were independently associated with increased risk of mortality. Receiver Operating Characteristic (ROC) analysis showed an AUC of 0.750 (95% CI: 0.649–0.865) for SII, with an optimal cutoff of 665.6 (sensitivity: 50%, specificity: 46%), and an AUC of 0.640 (95% CI: 0.519–0.769) for PIV, with a cutoff of 512.5 (sensitivity: 53%, specificity: 47%).

Conclusion: SII and PIV measured at hospital admission may serve as useful prognostic markers for predicting in-hospital mortality in patients with acute MP.

Author ORCID Identifier

HATİCE ŞAHİN: 0000-0002-7146-4828

GÜLAY ULUSAL OKYAY: 0000-0003-0770-1283

FATMA AYERDEN EBİNÇ: 0000-0002-7893-3498

FEVZİ SÖKMEN: 0000-0002-5621-8274

EMRE YAŞAR: 0000-0001-8271-1831

GÜLŞEN AKÇAY: 0000-0001-8377-5239

MEHMET AYLI: 0000-0003-3145-1595

DOI

10.55730/1300-0144.6050

Keywords

Inflammation, methanol, poisoning, mortality

First Page

971

Last Page

981

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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