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Turkish Journal of Medical Sciences

Abstract

Background/aim: This research examined the association between the triglyceride-glucose (TyG) index and metabolic, hepatic, and hematologic variables in a population of severely obese subjects, with a focus on the assessment of glycemic control.

Materials and methods: This retrospective study included 315 adult patients with a body mass index (BMI) ≥ 35 kg/m² who were evaluated for bariatric surgery. Participants were grouped according to HbA1c levels: those with HbA1c ≥ 6.5% and those with HbA1c < 6.5%. TyG, atherogenic index of plasma (AIP), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), and hematological inflammation markers were assessed and compared between groups. To investigate associations, correlation and regression analyses were conducted.

Results: Individuals with HbA1c ≥ 6.5% had significantly higher TyG, AIP, APRI, and FIB-4 values than those with lower HbA1c. The TyG index showed a strong correlation with both HbA1c (r = 0.403, p < 0.001) and AIP (r = 0.866, p < 0.001), and was identified as an independent predictor of HbA1c, explaining 20.5% of its variance. Moderate correlations were also found between liver fibrosis scores and systemic inflammatory indices. No significant differences were observed in hematologic markers across HbA1c groups, suggesting a closer link between inflammation and obesity rather than glycemic status.

Conclusion: The TyG index may serve as a practical and accessible marker for metabolic risk and glycemic control in obese individuals. Its integration with other noninvasive indices like AIP, APRI, and FIB-4 may support a more comprehensive evaluation of cardiometabolic and hepatic risk profiles in clinical settings.

Author ORCID Identifier

ÖZGE BAŞ AKSU: 0000-0003-3124-9477

FERİDE ÖZKARA: 0000-0001-7255-9995

RIFAT EMRAL: 0000-0002-5732-2284

VOLKAN GENÇ: 0000-0003-3883-4791

DEMET CORAPCIOGLUCORAPÇIOĞLUÇORAPÇIOĞLU: 0000-0003-0940-9147

MUSTAFA ŞAHİN: 0000-0002-4718-0083

DOI

10.55730/1300-0144.6019

Keywords

AIP, diabetes mellitus, FIB4, Obesity, TyG index

First Page

710

Last Page

718

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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