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Turkish Journal of Medical Sciences

Abstract

Background/aim: The objective of this study is to evaluate the effect of empagliflozin on cyclophosphamide-induced neurotoxicity in rats.Materials and methods: A total of 32 male Wistar rats were separated into 4 groups as 8 rats each: control group, cyclophosphamide group, empagliflozin group and the cyclophosphamide plus empagliflozin group. At the end of the experiment rats' brains were removed for biochemical analysis of oxidative stress parameters (malondialdehyde, total sulfhydryl, total oxidant status and total antioxidant capacity) and histopathological analysis.Results: Total sulfhydryl levels were increased in group empagliflozin and group empagliflozin and cyclophosphamide compared to the cyclophosphamide group but did not improve histopathological findings. Furthermore, when empagliflozin treatment was used coupled with cyclophosphamide, necrosis was significantly higher. Conclusion: In conclusion, empagliflozin has no protective effect on cyclophosphamide neurotoxicity in addition it may have neurotoxic effects. Clarification of possible neurotoxic/neuroprotective effects of empagliflozin would be beneficial for diabetic cancer patients who are receiving cyclophosphamide chemotherapy and empagliflozin together.

Author ORCID Identifier

ŞERİFEŞERİFE EZGİ DOĞAN: 0000-0003-0526-7647

ŞERİFEŞERİFE MEHLİKA KUŞKONMAZ: 0000-0002-2602-1657

PINAR CELEPLİ: 0000-0001-7643-6263

MEHMET ŞENES: 0000-0002-7924-5478

SEMA HÜCÜMENOĞLU: 0000-0002-6898-4101

CAVİT ÇULHA: 0000-0001-6563-8900

DOI

10.55730/1300-0144.5943

Keywords

Cyclophosphamide neurotoxicity, empagliflozin, rat brain

First Page

65

Last Page

71

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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