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Turkish Journal of Medical Sciences

Author ORCID Identifier

MUSTAFA GENÇELİ: 0000-0001-9455-2735

TALHA ÜSTÜNTAŞ: 0009-0004-2385-0953

ÖZGE AKCAN: 0000-0002-3465-6994

SİNAN SAYLIK: 0009-0007-7683-668X

FATİH ERCAN: 0000-0001-5252-7806

SEVGİ PEKCAN: 0000-0002-8059-902X

SİPİL GENÇELİ: 0000-0002-2923-9571

SEVGİ DURMUŞ: 0000-0003-4226-7312

MUSTAFA ARGUN: 0000-0003-2357-7980

DOI

10.55730/1300-0144.5905

Abstract

Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p<0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p<0.001), while cough and runny nose were significantly more common in AI (p<0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p<0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, ≤60 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP <124.5 mg/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.

Keywords

Adenovirus infection, multisystem inflammatory syndrome in children, scoring

First Page

1237

Last Page

1243

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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