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Turkish Journal of Medical Sciences

Author ORCID Identifier

SERHAT ÇETİN: 0000-0001-5450-5168

SERDAR ÇELİK: 0000-0003-0939-9989

MURAT KOPARAL: 0000-0002-8347-5727

GÜVEN ASLAN: 0000-0003-3715-1761

SERTAÇ YAZICI: 0000-0001-9616-3776

BAHADIR ŞAHİN: 0000-0002-4874-4178

SİNAN SÖZEN: 0000-0002-2573-3927

LEVENT TÜRKERİ: 0000-0002-6806-8349

DOI

10.55730/1300-0144.5916

Abstract

Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of Urological Pathology Grade Group (ISUP GG) upgrade rates of RR and ER systems were compared between biopsy and radical prostatectomy pathologies.Results: The matched sample included 157 RR and 157 ER patients. No statistically significant difference was found between ER and RR in terms of the csPC detection rate (28.0% vs. 22.3%, p = 0.242, respectively). The detection rate of all cancers by ER compared to RR was found to be significantly higher (54.8% vs. 35.7%, p < 0.001, respectively). No statistically significant difference was found between the ER and RR groups regarding pathological upgrade (39.7% vs. 24.2%, p = 0.130, respectively). In the logistic regression analysis performed to determine the factors predicting ciPC, decreased prostate volume and ER system use were found to be independent predictive factors.Conclusion: While the detection rate of csPC was similar for the RR and ER systems, the detection rate of all cancers and ciPC was significantly higher in ER systems.

Keywords

elastic, Prostate cancer, rigid, targeted biopsy

First Page

1327

Last Page

1334

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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