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Turkish Journal of Medical Sciences

Author ORCID Identifier

AYSUN AKSOY: 0000-0002-8218-7109

CEMAL GÜNDOĞMUŞ: 0000-0001-8662-994X

MEHMET KESİMER: 0000-0002-7474-6054

KEMAL NAS: 0000-0002-5845-0851

İKRAM DUMAN: 0000-0003-2791-8324

GAZANFER EKİNCİ: 0000-0001-5223-849X

MURAT BEZER: 0000-0001-8457-2978

PAMİR ATAGÜNDÜZ: 0000-0002-6393-7461

DOI

10.55730/1300-0144.5915

Abstract

Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine radiographs of 104 AS patients and clinical data are analyzed according to radiographic damage in the spine.AS patients were grouped as with or without syndesmophytes. Patients with complete bridging in at least one vertebral unit were excluded. Sacral slope,pelvic tilt,pelvic incidence,and lumbar lordosis were measured. Results: The mean disease duration was 14.5 years, and 60% of AS patients were male. Groups were similar in terms of age, sex distribution,and disease duration. Although numerically higher in patients with syndesmophytes, the mean pelvic incidence of AS patients was not different between groups(55.2±13.6 vs. 57.2±15.4). The sacral slope was high in patients with lumbar syndesmophytes(p<.005).Conclusion:Sacral slope was significantly higher in patients with syndesmophytes, which in turn results in an increased lumbar lordosis. Our results imply that the individual shape of the spine affects the distribution of weight and tensile forces in AS, and some patients are possibly more prone to new bone formation due to altered repetitive micro-trauma in the general genetic background of AS.Prospective studies addressing this cross-sectional observation may contribute to the development of new treatment strategies addressing mechanical load and may aid in decreasing management cost of AS with the present biologic therapies targeting new bone formation.

Keywords

ankylosing spondylitis, lumbar lordosis, pelvic incidence, sacral slope, syndesmophyte

First Page

1319

Last Page

1326

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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