Antifibrotic treatment response comparison of progressive pulmonary fibrosis and idiopathic pulmonary fibrosis

Authors

BERNA AKINCI ÖZYÜREKFollow
KEREM ENSARİOGLUFollow
TUGCE SAHİN OZDEMİRELFollow
ESMA SEVİL AKKURTFollow
OZLEM OZDAGFollow
ESMA ZENBİLLİFollow

Author ORCID Identifier

BERNA AKINCI ÖZYÜREK: 0000-0003-0206-7615

KEREM ENSARİOGLU', 'ENSARİOĞLU: 0000-0002-0968-1549

TUGCE', 'TUĞÇE SAHİN OZDEMİREL', 'ŞAHİN ÖZDEMİREL: 0000-0003-1596-0082

ESMA', 'ESMA SEVİL AKKURT: 0000-0002-5416-3783

OZLEM', 'ÖZLEM OZDAG', 'ÖZDAĞ: 0000-0002-1530-6999

ESMA ZENBİLLİ: 0000-0001-9733-4717

DOI

10.55730/1300-0144.5866

Abstract

Background/Aim: Idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) are two entities categorized fibrotic lung diseases. With a similar clinical presentation and treatment modalities in many cases, the line differentiating two diseases may not be evident. We aimed to evaluate the effectiveness of antifibrotic treatment and the course of fibrotic lung diseases. Material and Methods: The study included patients diagnosed with IPF and PPF who were given antifibrotic treatment and followed up for one year in our clinic. At one year, treatment response and radiological evaluation were investigated by high-resolution computed tomography. Results: Eighty-seven patients were included in the study (57 with IPF and 30 with PPF). Under antifibrotic treatment, there were no statistically significant losses in 6MWT, FVC, and DLCO values at the 6-month and 12-month evaluations. The most common side effects were photosensitivity for patients under the pirfenidone regimen, while diarrhea was predominantly observed in the PPF group. Radiological progression was observed in 22.9% of all patients at the yearly evaluation. Hospitalization requirements were more evident in the PPF group, with at least one hospitalization history present in 60% (n=18) of patients compared to 12.3% (n=7) of IPF patients. Conclusion: A personalized approach is preferred with similar clinical profiles for both treatment modalities, with specific side effects considered.

Keywords

antifibrotic treatment, İdiopathic pulmonary fibrosis, prognosis, progression, progressive pulmonary fibrosis

First Page

900

Last Page

907

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

AKINCI ÖZYÜREK, BERNA; ENSARİOGLU, KEREM; SAHİN OZDEMİREL, TUGCE; AKKURT, ESMA SEVİL; OZDAG, OZLEM; and ZENBİLLİ, ESMA (2024) "Antifibrotic treatment response comparison of progressive pulmonary fibrosis and idiopathic pulmonary fibrosis," Turkish Journal of Medical Sciences: Vol. 54: No. 5, Article 5. https://doi.org/10.55730/1300-0144.5866
Available at: https://journals.tubitak.gov.tr/medical/vol54/iss5/5