Antiobesity and antidyslipidemic properties of Clitoria ternatea petals aqueous extract against rats induced by high-fat diet

Authors

I Gede Aswin Parisya SASMANA, Udayana University Faculty of Medicine: Universitas Udayana Fakultas KedokteranFollow
Desak Made WIHANDANI, Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
I Gede Krisna Arim SADEVA, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Wilson HALIM, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Putu Putri AGUSTINI, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Lalita SAMALA, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
I Gusti Ngurah Agung Surya PRATAMA, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Lidiya Nuraliza RACHMAWATI, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Aizar Vesa PRASETYO, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow
Ni Komang Ayu Amanda Setiari JAYA, Faculty of Medicine, Udayana University, Denpasar, IndonesiaFollow

DOI

10.55730/1300-0144.5805

Abstract

Background/aim: Obesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world’s population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT’s petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials and methods: The CTE was obtained through the aqueous extract method and then was investigated using spectrophotometry to determine anthocyanin and tannin content. The effect of CTE against a high-fat diet (HFD)-induced rat model was measured by weight and obesity index, lipid profile (total cholesterol (TC), triglycerides (TG), and HDL-C), and histopathology analysis.Results: CTE showed total anthocyanin and tannin content of 78.0943 mg/100 g and 1424.90 mg/100 g, respectively. The data analysis also showed significantly different within groups (p < 0,05), especially between HFD and HFD + CT750 groups on the cholesterol (MD 111.12 mg/dL; 95% CI (99.57 to 122.67); p < 0.001), LDL (MD; 76.38 mg/dL; 95% CI (56.77 to 96.00); p < 0.001), VLDL (MD 0.37 mg/ dL; 95% CI (0.18 to 0.57); p < 0.001), body weight (MD: 56.20 g; 95% CI (13.89 to 98.51); p = 0.012); and thickening of tunica layer in the thoracic aorta (MD 22.76 μm; 95% CI (20.11 to 24.4); p < 0.001).Conclusion: This study shows that Clitoria ternatea petals aqueous extract promotes amelioration of the lipid profile, body weight, and tunica thickness in rats with the high-fat diet.

Keywords

Anthocyanin, Clitoria ternatea, dyslipidemia, high-fat diet, in vivo, obesity

First Page

401

Last Page

410

Recommended Citation

SASMANA, I Gede Aswin Parisya; WIHANDANI, Desak Made; SADEVA, I Gede Krisna Arim; HALIM, Wilson; AGUSTINI, Putu Putri; SAMALA, Lalita; PRATAMA, I Gusti Ngurah Agung Surya; RACHMAWATI, Lidiya Nuraliza; PRASETYO, Aizar Vesa; and JAYA, Ni Komang Ayu Amanda Setiari (2024) "Antiobesity and antidyslipidemic properties of Clitoria ternatea petals aqueous extract against rats induced by high-fat diet," Turkish Journal of Medical Sciences: Vol. 54: No. 2, Article 6. https://doi.org/10.55730/1300-0144.5805
Available at: https://journals.tubitak.gov.tr/medical/vol54/iss2/6