Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets

Authors

ESRA GÜZEL TANOĞLU
SEYFURE ADIGÜZEL
ALPASLAN TANOĞLU
ZEHRA BETÜL AYDIN
GÜLİZAR HOCAOĞLU
SAMET EBİNÇ

DOI

10.55730/1300-0144.5724

Abstract

Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.

Keywords

Long noncoding RNA, cancer, pancreas, pancreas cancer, biomarker

First Page

1552

Last Page

1564

Recommended Citation

TANOĞLU, ESRA GÜZEL; ADIGÜZEL, SEYFURE; TANOĞLU, ALPASLAN; AYDIN, ZEHRA BETÜL; HOCAOĞLU, GÜLİZAR; and EBİNÇ, SAMET (2023) "Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets," Turkish Journal of Medical Sciences: Vol. 53: No. 6, Article 4. https://doi.org/10.55730/1300-0144.5724
Available at: https://journals.tubitak.gov.tr/medical/vol53/iss6/4