Neurodevelopmental evaluation of newborns who underwent hypothermia with a diagnosis of hypoxic ischemic encephalopathy based on the Bayley-III scale

Authors

MEHMET FATİH DEVECİ
ŞENAY GÜVEN BAYSAL
MERAL ALAGÖZ
İSMAİL KÜRŞAD GÖKÇE
DERYA DOĞAN
RAMAZAN ÖZDEMİR

DOI

10.55730/1300-0144.5748

Abstract

Background/ aim: Hypoxic ischemic encephalopathy (HIE) is one of the common causes of mortality and morbidity in newborns. Despite therapeutic hypothermia, an important treatment with proven efficacy, the morbidity and mortality rates remain high. The aim of this study was to neurodevelopmentally evaluate patients who underwent therapeutic hypothermia. Material and method: Included herein were patients who underwent hypothermia between 2018 and 2020. Their medical files were reviewed retrospectively, and their demographic and clinical information was recorded. Patients whose contact information was available were called to the developmental pediatrics outpatient clinic for a neurodevelopmental evaluation. The Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) was used as the evaluation tool. Laboratory values and clinical parameters of the patients were further analyzed. Results: It was found that 42 patients underwent hypothermia in 3 years, of whom 14 (33.3%) had died. Of the 28 patients who were discharged, 20 children could be reached, and a neurodevelopmental evaluation was performed. Developmental delay in the cognitive area was detected in 11 (55%) patients, delay in the language area was found in 9 (45%) patients, and delay in the motor area was found in 11 (55%) patients. The correlation and regression analysis results determined that the time to start cooling was the most effective common factor in all 3 fields of scoring. Conclusion: The time to start cooling is related to the neurodevelopmental outcomes of patients with HIE. The earlier cooling is started, the better the neurodevelopmental results. Despite therapeutic hypothermia, the neurodevelop ent of infants may be adversely affected. These patients should be followed-up neurodevelopmentally for a long time.

Keywords

Hypoxic ischemic encephalopathy, Bayley-III, therapeutic hypothermia, neurodevelopmental evaluation

First Page

1786

Last Page

1793

Recommended Citation

DEVECİ, MEHMET FATİH; BAYSAL, ŞENAY GÜVEN; ALAGÖZ, MERAL; GÖKÇE, İSMAİL KÜRŞAD; DOĞAN, DERYA; and ÖZDEMİR, RAMAZAN (2023) "Neurodevelopmental evaluation of newborns who underwent hypothermia with a diagnosis of hypoxic ischemic encephalopathy based on the Bayley-III scale," Turkish Journal of Medical Sciences: Vol. 53: No. 6, Article 28. https://doi.org/10.55730/1300-0144.5748
Available at: https://journals.tubitak.gov.tr/medical/vol53/iss6/28