Factors affecting patient-acceptable symptom states and treatment decision in familial Mediterranean fever

Authors

DERYA YILDIRIM
İBRAHİM VASİ
ERDİ TAHTA
RIZA CAN KARDAŞ
BURCUGÜL ÖZKIZILTAŞ
HAMİT KÜÇÜK
MEHMET AKİF ÖZTÜRK
ŞEMİNUR HAZNEDAROĞLU
BERNA GÖKER
ABDURRAHMAN TUFAN

DOI

10.55730/1300-0144.5547

Abstract

Background/aim: Familial Mediterranean fever [FMF] is the most common autoinflammatory disease characterized by inflammatory attacks of fever and polyserositis. Patients' quality of life is significantly affected due to recurrent excruciating pain attacks and complications. This study is performed to evaluate the parameters most affecting patients' satisfaction from treatment. Materials and methods: Three hundred and forty-six consecutive patients diagnosed with FMF were enrolled in this study. Current treatment, acute phase proteins, number, type, and severity of predominant attacks, absenteeism from work/school in the last three months were recorded, and the participants were asked whether they needed additional treatment to evaluate Patient Acceptable Symptom State (PASS) status. Results: Mean age of the overall group was 38.2 ± 11.7 years (62.4% female, 37.6% male). Two hundred and twenty-seven patients were treated with colchicine, 97 patients with colchicine plus Interleukin-1 (IL-1) antagonist, and 22 only with IL-1 antagonist (67.1%, 26.3%, 6.64% in order). Of the overall group, 33.8% (n = 117) believed to need additional treatment options. Additional treatment need of patients was significantly affected by work impairment due to attacks, absent days from work, disease activity, the discomfort of patients during attacks, the number of attacks, and treatment options; but not by the level of acute-phase proteins between attacks. Conclusion: PASS score is significantly related to clinical parameters and quality of life. Patients' PASS scores and treatment choices are notably affected by the severity and frequency of attacks and absenteeism from work/school. Clinical activity and quality of life should be evaluated at every visit to provide patients' satisfaction with treatment.

Keywords

Familial Mediterranean fever, patient-acceptable symptom state, treatment, patient participation

First Page

1991

Last Page

1996

Recommended Citation

YILDIRIM, DERYA; VASİ, İBRAHİM; TAHTA, ERDİ; KARDAŞ, RIZA CAN; ÖZKIZILTAŞ, BURCUGÜL; KÜÇÜK, HAMİT; ÖZTÜRK, MEHMET AKİF; HAZNEDAROĞLU, ŞEMİNUR; GÖKER, BERNA; and TUFAN, ABDURRAHMAN (2022) "Factors affecting patient-acceptable symptom states and treatment decision in familial Mediterranean fever," Turkish Journal of Medical Sciences: Vol. 52: No. 6, Article 30. https://doi.org/10.55730/1300-0144.5547
Available at: https://journals.tubitak.gov.tr/medical/vol52/iss6/30