Chronic obstructive pulmonary disease phenotypes in Turkey: the COPET study-a national, multicenter cross-sectional observational study

Authors

ESRA YAZAR
BURCU ARPINAR YİĞİTBAŞ
CAN ÖZTÜRK
MUKADDER ÇALIKOĞLU
GAZİ GÜLBAŞ
MUZAFFER ONUR TURAN
HÜLYA DOĞAN ŞAHİN
NURHAN SARIOĞLU
NEVİN TACİ HOCA
FULSEN BOZKUŞ
SEDA TURAL ÖNÜR
NİHAL ARZU MİRİCİ
NALAN OGAN
NİLGÜN YILMAZ DEMİRCİ
BURCU YORMAZ

DOI

10.55730/1300-0144.5416

Abstract

Background/aim: While mortality rates decrease in many chronic diseases, it continues to increase in COPD. This situation has led to the need to develop new approaches such as phenotypes in the management of COPD. We aimed to investigate the distribution, characteristics and treatment preference of COPD phenotypes in Turkey. Materials and methods: The study was designed as a national, multicenter, observational and cross-sectional. A total of 1141 stable COPD patients were included in the analysis. Results: The phenotype distribution was as follows: 55.7% nonexacerbators (NON-AE), 25.6% frequent exacerbators without chronic bronchitis (AE NON-CB), 13.9% frequent exacerbators with chronic bronchitis (AE-CB), and 4.8% with asthma and COPD overlap (ACO). The FEV1 values were significantly higher in the ACO and NON-AE than in the AE-CB and AE NON-CB (p < 0.001). The symptom scores, ADO (age, dyspnoea and FEV1 ) index and the rates of exacerbations were significantly higher in the AE-CB and AE NON-CB phenotypes than in the ACO and NON-AE phenotypes (p < 0.001). Treatment preference in patients with COPD was statistically different among the phenotypes (p < 0.001). Subgroup analysis was performed in terms of emphysema, chronic bronchitis and ACO phenotypes of 1107 patients who had thoracic computed tomography. A total of 202 patients had more than one phenotypic trait, and 149 patients showed no features of a specific phenotype. Conclusion: Most of the phenotype models have tried to classify the patient into a certain phenotype so far. However, we observed that some of the patients with COPD had two or more phenotypes together. Therefore, rather than determining which phenotype the patients are classified in, searching for the phenotypic traits of each patient may enable more effective and individualized treatment.

Keywords

ACO, chronic bronchitis, COPD, emphysema, phenotype

First Page

1130

Last Page

1138

Recommended Citation

YAZAR, ESRA; YİĞİTBAŞ, BURCU ARPINAR; ÖZTÜRK, CAN; ÇALIKOĞLU, MUKADDER; GÜLBAŞ, GAZİ; TURAN, MUZAFFER ONUR; ŞAHİN, HÜLYA DOĞAN; SARIOĞLU, NURHAN; HOCA, NEVİN TACİ; BOZKUŞ, FULSEN; ÖNÜR, SEDA TURAL; MİRİCİ, NİHAL ARZU; OGAN, NALAN; DEMİRCİ, NİLGÜN YILMAZ; and YORMAZ, BURCU (2022) "Chronic obstructive pulmonary disease phenotypes in Turkey: the COPET study-a national, multicenter cross-sectional observational study," Turkish Journal of Medical Sciences: Vol. 52: No. 4, Article 31. https://doi.org/10.55730/1300-0144.5416
Available at: https://journals.tubitak.gov.tr/medical/vol52/iss4/31