Turkish Journal of Medical Sciences
DOI
10.3906/sag-2012-270
Abstract
Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose obtained from the male and female rats and the values were statistically evaluated. Results: The NGF immunoreactivity was observed in acinus, excretory pars, excretorius ducts, and islets of Langerhans for the pancreatic tissues of female and male rats in all groups. The Trk-A immunoreactivity was observed in acinus and islets of Langerhans for the pancreatic tissues of female and male rats in the control, sham, and cinnamon groups. Conclusion: As a result, it was determined that the cinnamon, which is effective on blood glucose levels, has a positive effect on the NGF production in pancreas.
Keywords
Cinnamon, diabetes, female and male rats, NGF, pancreas, Trk-A
First Page
2771
Last Page
2785
Recommended Citation
ARAS, ŞÜKRAN YEDİEL and SARI, EBRU KARADAĞ
(2021)
"An immunohistochemical examination of cinnamon extract administration ondistribution of NGF (nerve growth factor) and Trk-A (tyrosine kinase-A) receptor fordiabetic rats with pancreatic tissue,"
Turkish Journal of Medical Sciences: Vol. 51:
No.
5, Article 67.
https://doi.org/10.3906/sag-2012-270
Available at:
https://journals.tubitak.gov.tr/medical/vol51/iss5/67
