Histopathological effects of aloe vera on wound healing process in penile fracture model:an experimental study

Authors

KADİR TURGAY AKGÜL
ENGİN DOĞANTEKİN
ELİF ÖZER
MUSTAFA SIRRI KOTANOĞLU
YUSUF GÖKKURT
SEMA HÜCÜMENOĞLU

Abstract

Background/aim: This study assessed the histopathological effects of aloe vera (AV) on penile fractures (PF) formed experimentally in rat model. Materials and methods: Thirty-two Wistar adult male rats (220 to 250 g) were used. The PF model was created experimentally with a number 15 lancet. After the interventions, all of the rats were randomly and equally divided into 4 groups. In the first group, incision was not closed (group C). In the second group, AV was locally applied onto incision without suturing for 3 days (group AV). In the third group, the incision line was closed primarily (group PR). In the last group, AV was applied to primary repair region for 3 days (group PAV). All groups were compared to each other according to presence of fibrosis, inflammation, and hyperemia-bleeding. Results: Hyperemia and bleeding were seen in all groups with varying degrees and the difference between groups was insignificant (p = 1.000). According to inflammation, there was a significant difference between all groups (p = 0.031). No significant inflammation was observed in group AV and therefore, group AV had a better score than group PR (p = 0.026). In group PAV, inflammation was less seen than group PR, however, the difference was insignificant (p = 0.119). According to fibrosis, group AV and group PAV had same fibrosis rates. Fibrosis was observed in 2 (25%) rats in each group. When group PR was compared with group AV and group PAV, there were no significant differences according to cavernosal tissue healing with fibrosis (p = 0.132 and p = 0.132, respectively). Conclusion: Local application of AV onto the PF region without closing with suture decreased inflammation in rats.

DOI

10.3906/sag-2102-224

Keywords

Penile fracture, aloe vera, wound healing, penis

First Page

2193

Last Page

2197

Recommended Citation

AKGÜL, KADİR TURGAY; DOĞANTEKİN, ENGİN; ÖZER, ELİF; KOTANOĞLU, MUSTAFA SIRRI; GÖKKURT, YUSUF; and HÜCÜMENOĞLU, SEMA (2021) "Histopathological effects of aloe vera on wound healing process in penile fracture model:an experimental study," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 78. https://doi.org/10.3906/sag-2102-224
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/78