Lutein/zeaxanthin isomers regulate neurotrophic factors and synaptic plasticity intrained rats

Authors

CEMAL ORHAN
FÜSUN ERTEN
BEŞİR ER
MEHMET TUZCU
NURHAN ŞAHİN
ÖZNUR ECE DURMAZ KURŞUN
Vijaya Juturu
KAZİM ŞAHİN

DOI

10.3906/sag-2101-264

Abstract

Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p

Keywords

Lutein, zeaxanthin, exercise, oxidative stress, synaptic proteins

First Page

2167

Last Page

2176

Recommended Citation

ORHAN, CEMAL; ERTEN, FÜSUN; ER, BEŞİR; TUZCU, MEHMET; ŞAHİN, NURHAN; KURŞUN, ÖZNUR ECE DURMAZ; Juturu, Vijaya; and ŞAHİN, KAZİM (2021) "Lutein/zeaxanthin isomers regulate neurotrophic factors and synaptic plasticity intrained rats," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 75. https://doi.org/10.3906/sag-2101-264
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/75