Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugsin children in Turkey

Authors

NERİMAN İPEK KIRMIZI
VOLKAN AYDIN
NARİN AKICI
BANU BAYAR
AHMET AKICI

Abstract

Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (

DOI

10.3906/sag-2012-355

Keywords

Off-label drug use, pediatrics, rare disease, biotechnological drugs, canakinumab

First Page

1791

Last Page

1799

Recommended Citation

KIRMIZI, N. İ, AYDIN, V, AKICI, N, BAYAR, B, & AKICI, A (2021). Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugsin children in Turkey. Turkish Journal of Medical Sciences 51 (4): 1791-1799. https://doi.org/10.3906/sag-2012-355