Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects

Authors

HAKAN EMMUNGİL
UFUK İLGEN
RAFİ HANER DİRESKENELİ

DOI

10.3906/sag-2011-235

Abstract

Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the nonHLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory T cell function, and specific autoantibodies such as anti-PsA peptide, anti-LL-37, and anti-ADAMTSL5 are the immunopathological findings suggestive of autoimmunity. These were supported by clinical observations of autoimmune multimorbidity and treatment response to calcineurin/mTOR and co-stimulation inhibition.

Keywords

Autoantibody, autoimmunity, genetic, psoriasis, psoriatic arthritis

First Page

1601

Last Page

1614

Recommended Citation

EMMUNGİL, HAKAN; İLGEN, UFUK; and DİRESKENELİ, RAFİ HANER (2021) "Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 1. https://doi.org/10.3906/sag-2011-235
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/1