Importance of 14-3-3eta, anti-CarP, and anti-Sa in the diagnosis of seronegative rheumatoid arthritis

Authors

EMRAH SALMAN
SALİH ÇETİNER
BARIŞ BORAL
FİLİZ KİBAR
EREN ERKEN
EMİNE DUYGU ERSÖZLÜ
SUADE ÖZLEM BADAK
REYHAN BİLİCİ SALMAN
YAŞAR SERTDEMİR
ALEV ÇETİN DURAN
AKGÜN YAMAN

DOI

10.3906/sag-1812-137

Abstract

Background/aim: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation. The study aimed to assess serum 14-3-3eta, anti-CarP, and anti-Sa in seronegative RA (SNRA) patients who were treatment-naïve as well as in healthy subjects. This is the first study in the literature to examine these autoantibodies together in SNRA patients. Materials and methods: Forty-five treatment-naïve SNRA patients and 45 healthy subjects were recruited. Drugs change the levels of autoantibodies; therefore, patients who took any medication had been excluded from our study. Anti-carbamylated protein, anti-Sa, and 14-3-3eta were measured by using three different ELISA kits.Results: Median serum concentration of healthy controls in 14-3-3eta was 0.02 (0.02?0.27) ng/mL. Median serum concentration of SNRA patients in 14-3-3eta was 1.00 (0.48?1.28) ng/mL. Data were analyzed with Mann?Whitney U tests; the P-value was

Keywords

14-3-3eta, Anti-carP, Anti Sa, seronegative

First Page

1498

Last Page

1502

Recommended Citation

SALMAN, EMRAH; ÇETİNER, SALİH; BORAL, BARIŞ; KİBAR, FİLİZ; ERKEN, EREN; ERSÖZLÜ, EMİNE DUYGU; BADAK, SUADE ÖZLEM; SALMAN, REYHAN BİLİCİ; SERTDEMİR, YAŞAR; DURAN, ALEV ÇETİN; and YAMAN, AKGÜN (2019) "Importance of 14-3-3eta, anti-CarP, and anti-Sa in the diagnosis of seronegative rheumatoid arthritis," Turkish Journal of Medical Sciences: Vol. 49: No. 5, Article 34. https://doi.org/10.3906/sag-1812-137
Available at: https://journals.tubitak.gov.tr/medical/vol49/iss5/34