Turkish Journal of Medical Sciences
Abstract
Background/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined.Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center.Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 2-2, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 ± 1472 mg/dL) than the mean TG level afterwards (948 ± 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE.Conclusion: TPE is a safe, fast, and effective treatment modality in experienced centers.
DOI
10.3906/sag-1811-105
Keywords
Hypertriglyceridemia, pancreatitis, apheresis, therapeutic plasma exchange, fresh frozen plasma
First Page
872
Last Page
878
Recommended Citation
ŞİMŞİR, I. Y, SOYALTIN, U. E, YÜREKLİ, B. P, ERDOĞAN, M, ÇETİNKALP, Ş, SAYGILI, L. F, DÖNMEZ, A, & ÖZGEN, A. G (2019). Therapeutic plasma exchange in hypertriglyceridemic patients. Turkish Journal of Medical Sciences 49 (3): 872-878. https://doi.org/10.3906/sag-1811-105
