Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Authors

ASUMAN ÖZGÖZ
MURAT ŞAMLI
DENİZ DİNÇEL
AHMET ŞAHİN
ÜMİT İNCE
YEŞİM SAĞLICAN
FARUK BALCI
HALE ŞAMLI

Abstract

Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

DOI

10.3906/sag-1603-54

Keywords

Bladder cancer, polymorphism, B7-H4 gene

First Page

443

Last Page

446

Recommended Citation

ÖZGÖZ, ASUMAN; ŞAMLI, MURAT; DİNÇEL, DENİZ; ŞAHİN, AHMET; İNCE, ÜMİT; SAĞLICAN, YEŞİM; BALCI, FARUK; and ŞAMLI, HALE (2017) "Association of B7-H4 gene polymorphisms in urothelial bladder cancer," Turkish Journal of Medical Sciences: Vol. 47: No. 2, Article 12. https://doi.org/10.3906/sag-1603-54
Available at: https://journals.tubitak.gov.tr/medical/vol47/iss2/12