Turkish Journal of Medical Sciences
DOI
10.3906/sag-1410-55
Abstract
Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean CIMT value was 0.76 ± 0.15 mm, and median cathepsin D level was 190.3 (12.8-2681.3) ng/mL. A marked positive correlation was found between cathepsin D levels and CIMT (r = 0.331, P = 0.04). In multivariate linear regression analysis, cathepsin D, albumin levels, and the duration of hypertension were significant predictors of CIMT (P = 0.017, P = 0.008, and P = 0.043, respectively). Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.
Keywords
Atherosclerosis, cathepsin D, carotid intima-media thickness, hypertension
First Page
13
Last Page
17
Recommended Citation
ÖZKAYAR, NİHAL; AKYEL, FATMA; BARÇA, AYŞE NURDAN; PİŞKİNPAŞA, SERHAN VAHİT; TURHAN, TURAN; ATEŞ, İHSAN; and DEDE, FATİH
(2016)
"The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients,"
Turkish Journal of Medical Sciences: Vol. 46:
No.
1, Article 3.
https://doi.org/10.3906/sag-1410-55
Available at:
https://journals.tubitak.gov.tr/medical/vol46/iss1/3