Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

Authors

İKBAL KAYGUSUZ
SERAP AYNUR SİMAVLI
AYLA ESER
İLKNUR İNEGÖL GÜMÜŞ
SELCEN YÜKSEL
ZEHRA CANDAN İLTEMİR DUVAN
HASAN KAFALI

DOI

10.3906/sag-1311-88

Abstract

To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

Keywords

Mean platelet volume, menopause, cardiovascular risk, hormone replacement therapy, lipid profile

First Page

980

Last Page

984

Recommended Citation

KAYGUSUZ, İKBAL; SİMAVLI, SERAP AYNUR; ESER, AYLA; GÜMÜŞ, İLKNUR İNEGÖL; YÜKSEL, SELCEN; DUVAN, ZEHRA CANDAN İLTEMİR; and KAFALI, HASAN (2014) "Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women," Turkish Journal of Medical Sciences: Vol. 44: No. 6, Article 11. https://doi.org/10.3906/sag-1311-88
Available at: https://journals.tubitak.gov.tr/medical/vol44/iss6/11