Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds

Authors

WAQAR AHMAD KALEEM
MUHAMMAD NISAR
Mughal QAYUM
MUHAMMAD ZIA-UL-HAQ
MUHAMMAD IQBAL CHOUDHARY
SEZAİ ERCİŞLİ

DOI

10.3906/sag-1208-28

Abstract

To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew. Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition. Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2). Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.

Keywords

Zizyphus oxyphylla, cyclopeptide alkaloids, urease

First Page

497

Last Page

500

Recommended Citation

KALEEM, WAQAR AHMAD; NISAR, MUHAMMAD; QAYUM, Mughal; ZIA-UL-HAQ, MUHAMMAD; CHOUDHARY, MUHAMMAD IQBAL; and ERCİŞLİ, SEZAİ (2013) "Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds," Turkish Journal of Medical Sciences: Vol. 43: No. 4, Article 1. https://doi.org/10.3906/sag-1208-28
Available at: https://journals.tubitak.gov.tr/medical/vol43/iss4/1