Urginea maritima (L.) Baker (Liliaceae) extract induces more cytotoxicity than standard chemotherapeutics in the A549 non-small cell lung cancer (NSCLC) cell line

Authors

HAKAN BOZCUK
MUSTAFA ÖZDOĞAN
OKTAY AYKURT
FATİH TOPÇUOĞLU
HASAN ÖZTÜRK
DENİZ EKİNCİ
ASUMAN KARADENİZ
AYLİN MUTLU
DURMUŞ BURGUCU

DOI

10.3906/sag-0904-28

Abstract

Urginea maritima (Um) is a plant native to especially Turkey and the Mediterranean area. In this study, we investigated whether Um extract exerted cytotoxicity on cancer cells. Materials and methods: We made various extracts of Um. These extracts in varying concentrations were added to an A549 NSCLC cell culture, alone or with gemcitabine and/or cisplatin. Growth inhibition was tested by the MTT assay and an Annexin V-FITC apoptosis detection kit Results: The onion Um extract (1 µg/mL) was more cytotoxic than cisplatin (1 µg/mL), gemcitabine (1 nm/mL), and leaf Um extract (1 µg/mL) with P < 0.001, P = 0.097, and P < 0.001, respectively. The efficacy of Um extract was further improved by the addition of an antioxidant cocktail to an IC_{50} value of 0.02 µg/mL. Conclusion: Um extract has been shown for the first time to be a strong candidate for drug development in solid tumors. Our studies continue to further define the specific antitumor compound(s) in this extract.

Keywords

Urginea maritima, cytotoxicity, apoptosis, MTT, non-small cell lung cancer

First Page

101

Last Page

108

Recommended Citation

BOZCUK, HAKAN; ÖZDOĞAN, MUSTAFA; AYKURT, OKTAY; TOPÇUOĞLU, FATİH; ÖZTÜRK, HASAN; EKİNCİ, DENİZ; KARADENİZ, ASUMAN; MUTLU, AYLİN; and BURGUCU, DURMUŞ (2011) "Urginea maritima (L.) Baker (Liliaceae) extract induces more cytotoxicity than standard chemotherapeutics in the A549 non-small cell lung cancer (NSCLC) cell line," Turkish Journal of Medical Sciences: Vol. 41: No. 1, Article 14. https://doi.org/10.3906/sag-0904-28
Available at: https://journals.tubitak.gov.tr/medical/vol41/iss1/14