The predictive role of AST level, prothrombin time, and platelet count in the detection of liver fibrosis in patients with chronic hepatitis C

Authors

ÖZLEM KANDEMİR
GÜRBÜZ POLAT
GÜLİZ SARAÇOĞLU
BAHAR TAŞDELEN

DOI

10.3906/sag-0902-11

Abstract

Aim: We aimed to assess the predictive value of a combination some of basic serum biochemical markers for the diagnosis of clinically significant fibrosis in chronic hepatitis C. Materials and methods: Blood samples from 68 patients with chronic hepatitis C infection were analyzed for aspartate aminotransferase, prothrombin INR, and platelet count. The liver histopathology was evaluated using the Knodell protocol. The relationship between the serum biochemical markers and severity of the stages were examined. Results: A strong association was found between the fibrosis stage and platelet count and GUCI (P < 0.001, P = 0.035 respectively) but not APRI ([AST/ULN] / Platelet count [ ×109 /L]) × 100) (P = 0.052). The relationship between the platelet count

Keywords

Chronic hepatitis C, fibrosis, serum biochemical markers

First Page

857

Last Page

862

Recommended Citation

KANDEMİR, ÖZLEM; POLAT, GÜRBÜZ; SARAÇOĞLU, GÜLİZ; and TAŞDELEN, BAHAR (2009) "The predictive role of AST level, prothrombin time, and platelet count in the detection of liver fibrosis in patients with chronic hepatitis C," Turkish Journal of Medical Sciences: Vol. 39: No. 6, Article 6. https://doi.org/10.3906/sag-0902-11
Available at: https://journals.tubitak.gov.tr/medical/vol39/iss6/6