Decreased Placental Adrenomedullin May Play Role in Preeclampsia

Authors

REMZİ GÖKDENİZ
MUHİTTİN YÜREKLİ
ALANUR MENEKŞE
NURSEL BAZOĞLU

DOI

-

Abstract

Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p

Keywords

Preeclampsia, adrenomedullin, placental pathology.

First Page

281

Last Page

284

Recommended Citation

GÖKDENİZ, REMZİ; YÜREKLİ, MUHİTTİN; MENEKŞE, ALANUR; and BAZOĞLU, NURSEL (2000) "Decreased Placental Adrenomedullin May Play Role in Preeclampsia," Turkish Journal of Medical Sciences: Vol. 30: No. 3, Article 13. Available at: https://journals.tubitak.gov.tr/medical/vol30/iss3/13