Turkish Journal of Medical Sciences
DOI
-
Abstract
Cigarette smoke contains high concentrations of oxidants and reactive oxygen species. The aim of this study was to evaluate the effect of long-term cigarette smoking on glutathione (GSH) levels in bronchoalveolar lavage (BAL) fluid. Nineteen current cigarette smokers and seven healthy nonsmoking volunteers were included in the study. BAL was performed by infusion of five sequential 20 ml aliquots and each aliquot was immediately aspirated. The levels of GSH were determined in BAL fluids. The epithelial lining fluid volume was calculated by the ratio of urea concentration in BAL fluid to that in serum. Lower GSH levels were observed in the BAL fluid of current smokers than in that of nonsmokers (8.28 ± 0.78, 12.74 ± 1.09 µM respectively, p
Keywords
Bronchoalveolar lavage, Chronic obstructive pulmonary disease, Glutathione, Smoking.
First Page
643
Last Page
648
Recommended Citation
ALATAŞ, FÜSUN; ÖZDEMİR, NECLA; ALATAŞ, ÖZKAN; ERGİNEL, SİNAN; METİNTAŞ, MUZAFFER; and IŞIK, RANA (1999) "The Effects of Smoking on Glutathione Levels inBronchoalveolar Lavage Fluid," Turkish Journal of Medical Sciences: Vol. 29: No. 6, Article 9. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss6/9
