An Immunohistochemical Study of GastricNeuroendocrine Tumors: Expression ofProliferating Cell Nuclear Antigen andP53 Oncoprotein

Authors

GÜLEN DOĞUSOY
SÜHA GÖKSEL
IŞIL PAKİŞ
HAYDAR DURAK
GÖKHAN ERSOY
SELDA GÖÇENER

DOI

-

Abstract

The aim of this study is to examine expression of Proliferating cell nuclear antigen (PCNA) and p53 oncoprotein in gastric neuroendocrine tumors. 35 gastric neuroendocrine tumors were analyzed for first histopathologic features and then, immunohistochemical study was done to detect labeling index of PCNA and accumulation of p53 protein by using monoclonal antibodies and the Labeled strepavidin-biotin method. PCNA labeling index and p53 protein expression were compared with histopatholoic features in statistical methods of Fisher's exact, chi square and logistic regression tests. No significant correlation was found between them except PCNA score and depth of invasion. In conclusion, our findings show that not p53 but PCNA appears to be useful in detecting malignant potential of these tumors.

Keywords

Gastric neuroendocrine tumors, PCNA, p53 oncoprotein.

First Page

631

Last Page

636

Recommended Citation

DOĞUSOY, GÜLEN; GÖKSEL, SÜHA; PAKİŞ, IŞIL; DURAK, HAYDAR; ERSOY, GÖKHAN; and GÖÇENER, SELDA (1999) "An Immunohistochemical Study of GastricNeuroendocrine Tumors: Expression ofProliferating Cell Nuclear Antigen andP53 Oncoprotein," Turkish Journal of Medical Sciences: Vol. 29: No. 6, Article 7. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss6/7